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chemical structure namenda |
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chemical structure namenda Generic Name: memantine HCl Date of Approval: Manufacturer: Treatment for: The U.S chemical structure namenda. Food and Drug Administration (FDA) has approved Namenda (memantineHCl) for the treatment of moderate to severe Alzheimer's disease chemical structure namenda. Namenda isthe first NMDA receptor antagonist to be approved for Alzheimer's disease andis also the only therapy approved for the treatment of moderate to severe Alzheimer'sdisease. Namenda's FDA approval is based on the Agency's review of safety and efficacydata from two U.S chemical structure namenda. placebo-controlled Phase III clinical trials and an earliertrial conducted among nursing home patients in Europe chemical structure namenda. Phase III data includeda 28-week monotherapy study of 252 patients published earlier this year in theNew England Journal of Medicine and a six-month, 401-patient study of Namendawhen used together with an ongoing regimen of the commonly used Alzheimer'sagent, donepezil chemical structure namenda. In trials, patients treated with Namenda scored higher onmeasures of cognition, daily function, and/or global performance chemical structure namenda. This developmentprogram for memantine was a joint effort between Forest and its licensor, MerzPharmaceuticals, who obtained centralized approval for memantine in the EuropeanUnion in 2002 chemical structure namenda. Merz Pharmaceuticals is a specialty pharmaceutical company dedicatedto research and development in the fields of neurology and psychiatry. In clinical trials, Namenda has been safe and well tolerated chemical structure namenda. The most commonadverse events observed in clinical trials are dizziness, headache, constipation,and confusion chemical structure namenda. Once available in pharmacies, Namenda will be administered orallyat a recommended dose of 10 mg BID following a four-week titration. Alzheimer's is a progressive disease of the brain and it is the most commontype of dementia chemical structure namenda. The term dementia is used to describe the progressive lossof cognitive, intellectual, or functional abilities chemical structure namenda. Published reports projectthat by 2010 more than 5.1 million people in the United States will have Alzheimer'sdisease chemical structure namenda. Currently, all Alzheimer's medications approved in the United Statesbelong to a class of agents called acetylcholinesterase inhibitors, which areindicated for patients with mild to moderate symptoms of the disease chemical structure namenda. Namendais the only approved therapy in the United States for moderate to severe Alzheimer'sdisease.
Namenda (memantine HCl) is the first of a new class of medications for Alzheimer'sdisease with a mechanism of action distinct from currently available drugs chemical structure namenda. Namenda is a low to moderate affinity NMDA (N-methyl-D- aspartate) receptorantagonist chemical structure namenda. It is thought that overexcitation of NMDA receptors by the neurotransmitterglutamate may play a role in Alzheimer's disease since glutamate plays an integralrole in the neural pathways associated with learning and memory chemical structure namenda. The excitotoxicityproduced by abnormal levels of glutamate is thought to be responsible for neuronalcell dysfunction and the eventual cell death observed in Alzheimer's disease chemical structure namenda. Namenda is thought to selectively block the excitotoxic effects associated withabnormal transmission of glutamate, while allowing for the physiological transmissionassociated with normal cell functioning. |
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